Cryptotanshinone inhibits cytotoxin-associated gene A-associated development of gastric cancer and mucosal erosions

Figure 6 Cryptotanshinone inhibits cytotoxin-associated gene A-induced mucosal lesions in the stomach of mice. A: Mice were divided into four groups (n = 8 per group) and received the treatments indicated in the graphical representation; B: After the treatments, the mice were sacrificed, and the stomach was resected for hematoxylin and eosin (H&E) staining. The black arrow shows mucosal erosion; C: The mice were administered cryptotanshinone (CTS) (10 mg/kg) intragastrically for 1 mo, and the toxicity to the liver and kidney was assessed by H&E staining; D and E: Isolated Helicobacter pylori strains were authenticated through the polymerase chain reaction assay using specific primers. 1: Pre-Mouse Sydney Strain 1 (PMSS1) wild-type; 2: SS1 strain-isolated; 3: PMSS1 wild-type-isolated; 4: PMSS1 ∆cytotoxin-associated gene A (CagA)-isolated.