Cryptotanshinone inhibits cytotoxin-associated gene A-associated development of gastric cancer and mucosal erosions

Figure 5 Cryptotanshinone suppresses the expression of Src homology 2 domain–containing phosphatase 2 (SHP2) and the cytotoxin-associated gene A-induced phosphorylation of SHP2. A: AGS cells were transfected with pSR-HA-cytotoxin-associated gene A (CagA) or empty vector plasmid for 24 h and then treated with the indicated doses of cryptotanshinone (CTS) for 24 h; B: AGS cells were treated with the indicated doses of CTS for 24 h. Western blotting was performed to detect the expression of Src homology 2 domain–containing phosphatase 2 (SHP2) and phosphorylated SHP2. β-actin was used as a loading control.