Cryptotanshinone inhibits cytotoxin-associated gene A-associated development of gastric cancer and mucosal erosions

Figure 4 Cryptotanshinone inhibits the cytotoxin-associated gene A-induced migration and invasion of AGS cells. AGS cells were transfected with pSR-HA-cytotoxin-associated gene A (CagA) or an empty vector plasmid for 24 h and then treated with the indicated doses of cryptotanshinone (CTS) for 24 h. The cells were seeded into the upper transwell chamber. A and C: The invaded (A) and migrated (C) cells were stained and photographed; B and D: The histograms represent the numbers of invaded (B) and migrated (D) cells. Cells were counted from five randomly selected microscope fields. Data are expressed as the mean ± SD of triplicate experiments. ^bP < 0.01.