Sporadic fundic gland polyps with dysplasia or carcinoma: Clinical and endoscopic characteristics

Figure 1 A case of sporadic fundic gland polyp without dysplasia. A: White light endoscopic view. A 47-year-old man with a complaint of heartburn underwent esophagogastroduodenoscopy. He had no medical history of receiving long-term proton pump inhibitor therapy and no family history of familial adenomatous polyposis (FAP). White light endoscopy identified several fundic gland polyp-like lesions in the body of the stomach without atrophic mucosa, suggesting a Helicobacter pylori-uninfected setting. Among them, a 3 mm isochromatic sessile polyp with a smooth surface structure was detected in the middle body; B: Magnifying narrow-band imaging (NBI) endoscopic view. Magnifying NBI endoscopy revealed regularly arranged, white, dot-shaped crypt openings resembling surrounding mucosa; C: Chromoendoscopic view. Chromoendoscopy using indigo carmine dye revealed less irregularity of the lesion surface. This lesion was endoscopically diagnosed as a fundic gland polyp without dysplasia and was biopsied; D and E: Histopathological view. The histopathological examination revealed a non-dysplastic fundic gland polyp with hyperplastic proliferation of the oxyntic glands and several cystically dilated glands. Colonoscopy did not reveal indications for FAP.