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©The Author(s) 2021.
World J Gastrointest Oncol. Jul 15, 2021; 13(7): 716-731
Published online Jul 15, 2021. doi: 10.4251/wjgo.v13.i7.716
Published online Jul 15, 2021. doi: 10.4251/wjgo.v13.i7.716
Table 1 Patient baseline and correlation between protein phosphatase 2 regulatory subunit B''α expression and clinicopathologic characteristics in hepatocellular carcinoma
| Clinicopathological variable | Patients, n (%) | PPP2R3A expression levels | Statistical results | |
| < 4 | ≥ 4 | |||
| Gender | ||||
| Male | 105 (97.2) | 79 (73.1) | 26 (24.1) | P = 0.195; X2 = 1.679 |
| Female | 3 (2.8) | 3 (2.8) | 0 (0) | |
| Age (yr) | ||||
| ≤ 50 | 45 (41.7) | 37 (34.2) | 8 (7.4) | P = 0.255 |
| > 50 | 63 (58.3) | 45 (41.7) | 18 (16.7) | X2 = 1.673 |
| Preoperative treatment | ||||
| No | 59 (54.6) | 47 (43.5) | 12 (11.1) | P = 0.370 |
| Yes | 49 (45.4) | 35 (32.4) | 14 (13) | X2 = 0.993 |
| AFP (ng/mL) | ||||
| < 13 | 24 (22.2) | 21 (19.4) | 3 (2.8) | P = 0.0031; X2 = 11.513 |
| 13-1000 | 40 (37.0) | 35 (32.4) | 5 (4.6) | |
| > 1000 | 44 (40.8) | 26 (24.1) | 18 (16.7) | |
| HBeAg | ||||
| Negative | 72 (66.7) | 56 (51.9) | 16 (14.8) | P = 0.634 |
| Positive | 36 (33.3) | 26 (24.1) | 10 (9.2) | X2 = 0. 405 |
| HBV-DNA (copy/mL) | ||||
| ≤ 1 | 75 (69.4) | 57 (52.8) | 18 (16.7) | P = 1.000 |
| > 1 | 33 (30.6) | 25 (23.1) | 8 (7.4) | X2 = 0.001 |
| MELD | ||||
| < 15 | 85 (78.7) | 65 (60.2) | 20 (18.5) | P = 1.000 |
| ≥ 15 | 23 (21.3) | 17 (15.7) | 6 (5.6) | X2 = 0.065 |
| Child-Pugh | ||||
| A | 65 (60.2) | 52 (48.3) | 13 (12.0) | P = 0.424; X2 = 3.952 |
| B | 27 (25.0) | 17 (15.7) | 10 (9.2) | |
| C | 16 (14.8) | 13 (12.0) | 3 (2.8) | |
| Pathology | ||||
| Well differentiation | 5 (4.6) | 5 (4.6) | 0 (0) | P = 0.296 |
| Moderate differentiation | 98 (90.8) | 74 (68.5) | 24 (22.2) | X2 = 3.382 |
| Poor differentiation | 5 (4.6) | 3 (2.8) | 2 (1.9) | |
| TNM-t | ||||
| T1 | 46 (42.6) | 38 (35.2) | 8 (7.4) | P = 0.0001; X2 = 16.601 |
| T2 | 21 (19.4) | 21 (19.4) | 0 (0) | |
| T3 | 41 (38.0) | 23 (21.3) | 18 (16.7) | |
| Length (cm) | ||||
| ≤ 3 | 31 (28.7) | 24 (22.2) | 7 (6.5) | P = 0.198; X2 = 3.294 |
| 4-5 | 38 (35.2) | 32 (29.6) | 6 (5.6) | |
| ≥ 6 | 39 (36.1) | 26 (24.1) | 13 (12.0) | |
| Tumor number | ||||
| 1 | 36 (33.3) | 30 (27.8) | 6 (5.6) | P = 0.240 |
| ≥ 2 | 72 (66.7) | 52 (48.1) | 20 (18.5) | X2 = 1.621 |
| Microsatellite stove | ||||
| No | 55 (50.9) | 44 (40.7) | 11 (10.2) | P = 0.371 |
| Yes | 53 (49.1) | 38 (35.2) | 15 (13.9) | X2 = 1.018 |
| Envelope invasion | ||||
| No | 75 (69.4) | 57 (52.8) | 18 (16.7) | P = 0.0011 |
| Yes | 33 (30.6) | 25 (23.1) | 8 (7.4) | X2 = 1.000 |
| Vascular invasion | ||||
| No | 69 (63.9) | 53 (49.1) | 16 (14.8) | P = 0.817 |
| Yes | 39 (36.1) | 29 (26.9) | 10 (9.2) | X2 = 0.082 |
| Lymph node metastasis | ||||
| No | 92 (85.2) | 72 (66.7) | 20 (18.5) | P = 0.207 |
| Yes | 16 (14.8) | 10 (9.2) | 6 (5.6) | X2 = 1.707 |
| Liver metastasis | ||||
| No | 67 (62.0) | 55 (50.9) | 12 (11.1) | P = 0.066 |
| Yes | 41 (38.0) | 27 (25) | 14 (13) | X2 = 3.668 |
| Chest metastasis | ||||
| No | 75 (69.4) | 61 (56.5) | 14 (13) | P = 0.055 |
| Yes | 33 (30.6) | 21 (19.4) | 12 (11.1) | X2 = 3.927 |
| Hepatitis B | ||||
| No recurrence | 102 (94.4) | 78 (72.9) | 24 (22.4) | P = 0.427 |
| Recurrence | 5 (4.6) | 3 (2.8) | 2 (1.9) | X2 = 0.632 |
- Citation: He JJ, Shang L, Yu QW, Jiao N, Qiu S, Zhu WX, Wu DF, Tian YE, Zhang Q. High expression of protein phosphatase 2 regulatory subunit B'' alpha predicts poor outcome in hepatocellular carcinoma patients after liver transplantation. World J Gastrointest Oncol 2021; 13(7): 716-731
- URL: https://www.wjgnet.com/1948-5204/full/v13/i7/716.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v13.i7.716