Current role of hepatopancreatoduodenectomy for the management of gallbladder cancer and extrahepatic cholangiocarcinoma: A systematic review

Table 2 Studies reporting on morbidity and mortality outcomes for gallbladder cancer and extrahepatic cholangiocarcinoma after hepatopancreatoduodenectomy (years 2015-2020)

Ref.	Total n of patients	Morbidity (%)	Perioperative mortality (%)
Tran et al[23], 2015	107	87.53	18.24
Fukami et al[15], 2016	38	44.71	13.5
Fernandes et al[8], 2016	35	97.4	34.2
Aoki et al[21], 2016	52	37.01	0
Dai et al[13], 2017	12	83.3	25.0
Lee et al[41], 2018	22	68.2	4.5
Welch et al[9], 2019	23	87.0	26.0
Mizuno et al[37], 2019	38	87.01	18.0
D’Souza et al[10], 2019	66	50.01	15.0
Toyoda et al[43], 2019	100	81.01	0%2
Liu et al[11], 2020	16	62.5	12.5
Shimizu et al[28], 2020	37	51.41	5.4

¹≥ 3 Clavien grade 3 morbidity.

²100 patients were enrolled in the study after excluding 4 patients who died of surgical.

³Lobectomy or trisectionectomy with pancreaticoduodenectomy.

⁴In-hospital mortality complications.