Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer

doi:10.4251/wjgo.v13.i6.509

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Jun 15, 2021 (publication date) through Aug 24, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jun 15, 2021; 13(6): 509-535
Published online Jun 15, 2021. doi: 10.4251/wjgo.v13.i6.509

Table 2 Nucleos(t)ide analogs evaluated in woodchucks for safety and antiviral efficacy against hepatitis B virus

Antiviral drug	Abbreviation	Brand name	Ref.
Adefovir dipivoxil	ADV	Hepsera	[217-219]
Clevudine¹	CLV or L-FMAU	Levovir and Revovir	[172,220-222]
Emtricitabine	FTC	Coviracil	[219,221,223,224]
Entecavir¹	ETV	Baraclude	[171,225-228]
Lamivudine¹	LAM or 3TC	Epivir	[164,165,194,219,229]
Telbivudine	LdT	Tyzeka	[230-232]
Tenofovir alafenamide	TAF	Vemlidy	[233]
Tenofovir disoproxil fumarate	TDF	Viread	[219]
Valtorcitabine	LdC		[230-232]

¹Long-term treatment with these drugs delayed hepatocellular carcinoma (HCC) onset and extended HCC-free survival in woodchucks. See text for more details.

Citation: Suresh M, Menne S. Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer. World J Gastrointest Oncol 2021; 13(6): 509-535
URL: https://www.wjgnet.com/1948-5204/full/v13/i6/509.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i6.509