Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers

Table 1 Hypoxia induces the transcription of a range of genes that mediate diverse roles in promoting the hallmarks of cancer[178-180]

Function	Gene
Enzymes	MMP1, MMP3, LOX, ADAMST1, ACE
Transcription factors	Twist1, Snail, Slug, β-Catenin, c-Myc, Oct4, NF-κB
Receptors	CXCR4, c-Met, TLR4, Notch
Growth factors	VEGF, TGFα
Transporters	Glut-1, MDR1
Intracellular signalling	Cdc42, Rac1, RhoE
Bioenergetics	LDHA, PGK1, PKM2, GAPDH, GPI, ALDOC