Early diagnosis and therapeutic strategies for hepatocellular carcinoma: From bench to bedside

doi:10.4251/wjgo.v13.i4.197

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Apr 15, 2021 (publication date) through Feb 7, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2021; 13(4): 197-215
Published online Apr 15, 2021. doi: 10.4251/wjgo.v13.i4.197

Table 1 Non-invasive biomarkers for early diagnosis of hepatocellular carcinoma

Type of biomarker	Examples
Proteins	AFP; DCP; GALAD score; HES algorithm; ASAP model
Metabolites	A panel based on phenylalanyl-tryptophan and glycocholate
Circulating cell-free DNAs	Somatic mutations; DNA methylation; 5-hydroxymethylcytosine
Circulating non-coding RNAs	Micro-RNAs (mirR-125b, miR-122, and miR-21); Circular RNAs; Long non-coding RNAs; Exosomal non-coding RNAs

AFP: Alpha-fetoprotein; DCP: Des-gamma-carboxy prothrombin; HCC: Hepatocellular carcinoma; RNA: Ribonucleic acid.

Citation: Guan MC, Wang MD, Liu SY, Ouyang W, Liang L, Pawlik TM, Xu QR, Huang DS, Shen F, Zhu H, Yang T. Early diagnosis and therapeutic strategies for hepatocellular carcinoma: From bench to bedside. World J Gastrointest Oncol 2021; 13(4): 197-215
URL: https://www.wjgnet.com/1948-5204/full/v13/i4/197.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i4.197