Outcomes of curative esophageal cancer surgery in elderly: A meta-analysis

Table 3 Subanalysis of primary and secondary outcomes: open esophagectomy and minimally invasive esophagectomy

	Studies	Participants	Younger	Older	RR	95%CI		P value
	n	n	%	%
Primary outcomes
Anastomotic leak
OE	2	545	12.08	13.85	1.1307	0.2235	5.7199	0.5120
MIE	2	812	18.76	18.54	0.9996	0.1877	5.3243	0.9979
30-d mortality rate
OE	1	253	0.43	5.00	11.6500	0.7568	179.3310	0.0784
MIE	2	812	2.42	3.97	1.7320	0.0002	12493.0189	0.5761
90-d mortality rate
OE	2	403	0.60	2.86	6.8396	0.0279	1675.2496	0.1410
MIE	2	812	5.60	25.71	2.1859	0.2111	22.6353	0.1471
In-hospital morality rate
OE	1	292	8.10	24.44	3.0189	1.5547	5.8620	0.0011
MIE	1	446	3.08	4.49	1.4586	0.4757	4.4730	0.5091
Secondary outcomes
Chylothorax
OE	1	292	3.24	2.22	0.6861	0.0879	5.3534	0.7193
MIE	1	446	8.12	7.87	0.9682	0.4385	2.1377	0.9363
Pneumonia
OE	2	545	21.04	47.69	2.1531	0.0639	72.5068	0.2205
MIE	1	446	32.77	31.46	0.9600	0.6828	1.3497	0.8141

Standardized mean difference instead of relative risk. RR: Relative risk; 95%CI: 95% confidence interval. OE: Open esophagectomy; MIE: Minimally invasive esophagectomy.