Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure

doi:10.4251/wjgo.v13.i2.119

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Feb 15, 2021 (publication date) through Dec 1, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Gastrointest Oncol. Feb 15, 2021; 13(2): 119-130
Published online Feb 15, 2021. doi: 10.4251/wjgo.v13.i2.119

Table 4 Acute toxicity in all periods in both treatment groups

Toxicity	Standard therapy, n (%)	TNT, n (%)	P value
During systemic ChT			0.037¹
Without	12 (24)	16 (18)
Grade 1-2	31 (62)	70 (79)
Grade 3	7 (14)	3 (3)
During CRT			0.553¹
Without	13 (18)	21 (24)
Grade 1-2	57 (79)	64 (72)
Grade 3-4	2 (3)	4 (4)
Postoperative complications			0.140
Without	43 (61)	62 (76)
Grade 1-2	18 (26)	15 (18)
Grade 3-5	9 (13)	5 (6)

¹Likelihood-ratio test.

ChT: Chemotherapy; CRT: Chemoradiotherapy; TNT: Total neoadjuvant treatment.

Citation: Tuta M, Boc N, Brecelj E, Peternel M, Velenik V. Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure. World J Gastrointest Oncol 2021; 13(2): 119-130
URL: https://www.wjgnet.com/1948-5204/full/v13/i2/119.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i2.119