Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure

Table 2 Treatment characteristics

Characteristic		Standard therapy, n = 70, (%)	TNT, n = 82, (%)	P value
pCR		5 (7)	19 (23)	0.007
CR		7 (10)	23 (26)	0.009
NAR score	mean [SD]	16.8 [12.9]	10.7 [10.8]	0.002
NAR classes	< 8	9 (13)	35 (43)	< 0.001
	8-16	38 (56)	33 (40)
	> 16	21 (31)	14 (17)
Surgery	R0	65 (93)	78 (95)	0.4451
	R1	4 (6)	4 (5)
	R2	1 (1)	0 (0)
Weeks to stoma closure	mean [SD]	32.8 [18.6]	20.1 [10.9]	< 0.001

¹Likelihood-ratio test.

CR: Complete response; NAR: Neoadjuvant rectal; pCR: Pathological complete response; TNT: Total neoadjuvant treatment.