BRAFV600E mutant colorectal cancer cells mediate local immunosuppressive microenvironment through exosomal long noncoding RNAs

Figure 1 Relationship between BRAF^V600E mutation and microvascular density, microlymphatic vessel density, tumor-associated macrophages, and cancer-associated fibroblasts. A: Expression of CD31 and lymphatic vessel endothelial hyaluronic acid receptor-1 (LYVE-1) in BRAF^V600E mutant and BRAF wild type colorectal cancer (CRC) tissues (CD31 labeled microvascular density, and LYVE-1 labeled microlymphatic vessel density; immunohistochemistry, × 400); B: Expression of CD68 and CD163 proteins in BRAF^V600E mutant and BRAF wild type CRC tissues (CD68 labeled TAMs, and CD163 labeled M2 subtype macrophages; immunohistochemistry, × 400); C: Expression of α-SMA protein in BRAF^V600E mutant and BRAF wild type CRC tissues (α-SMA labeled CAFs; immunohistochemistry, × 400).