Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer

Figure 2 The molecular mechanisms involved in the contribution of diabetes mellitus to the remodeling of gastric cancer microenvironment determine crucial phenotypical changes not only on tumor cells but also in many other infiltrating cells. All changes may then result in a supporting tumor-growth niche that favors angiogenesis, invasion, and metastasis, as well as interference with anti-tumor immunity and thus generating more aggressive tumor phenotypes. ECM: Extracellular matrix.