Clinical features of intracerebral hemorrhage in patients with colorectal cancer and its underlying pathogenesis

Table 1 Demographics of colorectal cancer patients with intracerebral hemorrhage

Characteristics	mean ± SD/n (%)
Age, yr	68.45 ± 10.66
Gender
Male	13 (65)
Female	7 (35)
Vascular risk factors	10 (50)
Tobacco	6 (30)
Hypertension	6 (30)
Diabetes mellitus	2 (10)
Hypercholesterolemia	3 (15)
Alcohol abuse	1 (5)
Stroke history	2 (10)
Coronary or kidney disease	1 (5)
Coagulopathy	10 (50)
PLT < 100 × 109/L	6 (30)
PT > 15 s	6 (30)
APTT > 45 s	2 (10)
INR > 1.5	3 (15)
DIC	1 (5)
Elevated cancer biomarkers	17 (85)
CEA > 5 ng/mL	16 (80)
CA125 > 35 U/mL	4 (20)
CA153 > 31.3 U/mL	2 (10)
CA199 > 37 U/mL	9 (45)
Hepatic dysfunction
Yes	6 (30)
No	14 (70)
Distant metastasis
Intracranial metastasis	10 (50)
Hepatic/osseous metastasis	8 (40)
Metastasis of other organs	7 (35)
None	6 (30)
Cancer treatment before hemorrhage
Surgery alone	2 (10)
Chemotherapy	3 (15)
Both of the above	8 (40)
No treatment	7 (35)

PLT: Platelet; PT: Prothrombin time; APTT: Activated partial thromboplastin time; INR: International normalized ratio; DIC: Disseminated intravascular coagulation; CEA: Carcinoembryonic antigen; CA125: Carbohydrate antigen 125; CA153: Carbohydrate antigen 153; CA199: Carbohydrate antigen 199.