MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos

Table 3 Correlation of hMLH1 methylation and microsatellite instability status of paired samples

		hMLH1 methylation (%)
		M/M	M/U	U/M	U/U	Total	P value
MSI status	H/H	1 (5)	5 (26)	0 (0)	13 (68)	19	NS
	L/L	1 (13)	4 (50)	0 (0)	3 (37)	8
	S/S	0 (0)	1 (33)	0 (0)	2 (67)	3
	L/S or S/L	1 (10)	3 (30)	0 (0)	6 (60)	10
	L/H or H/L	1 (7)	2 (14)	1 (7)	10 (71)	14
	Total	4 (7)	15 (28)	1 (2)	34 (63)	54

MSI: Microsatellite instability; M: Methylated; U: Unmethylated; In paired normal/tumor tissues: M/M: Methylated/methylated; U/U: Unmethylated/unmethylated; M/U: Methylated/unmethylated; U/M: Unmethylated/methylated; In paired normal/tumor tissues: H/H: Microsatellite instability-high/microsatellite instability-high; L/L: Microsatellite instability-low/microsatellite instability-low; S/S: Microsatellite stable/microsatellite stable; L/S: Microsatellite instability-low/microsatellite stable; S/L: Microsatellite stable/microsatellite instability-low; L/H: Microsatellite instability-low/microsatellite instability-high; H/L: Microsatellite instability-high/microsatellite instability-low; NS: Not significant.