MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos

doi:10.4251/wjgo.v13.i12.2101

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Dec 15, 2021; 13(12): 2101-2113
Published online Dec 15, 2021. doi: 10.4251/wjgo.v13.i12.2101

Table 2 Microsatellite instability status in the Filipinos colorectal cancer patients

		Normal tissue (%)				Tumor tissue (%)				Normal/tumor (%)
		MSI-H	MSI-L	MSS	P value	MSI-H	MSI-L	MSS	P value	H/H	L/L	S/S	L/S or S/L	L/H or H/L	P value
	Freq	25	23	6		27	17	10		19	8	3	10	14
Gender
Male	30	12 (40)	15 (50)	3 (10)	NS	14 (47)	9 (30)	7 (23)	NS	9 (30)	4 (13)	1 (3)	8 (27)	8 (27)	NS
Female	24	13 (54)	8 (33)	3 (13)		13 (54)	8 (33)	3 (13)		10 (42)	4 (17)	2 (8)	2 (8)	6 (25)
Age
≤ 40	5	3 (60)	2 (40)	0 (0)	NS	2 (40)	1 (20)	2 (40)	NS	2 (40)	0 (0)	0 (0)	2 (40)	1 (20)	NS
> 40	49	22 (45)	21 (43)	6 (12)		25 (51)	16 (33)	8 (16)		17 (35)	8 (16)	3 (6)	8 (16)	13 (27)
Location of tumor
Proximal	6	4 (67)	2 (33)	0 (0)	NS	4 (67)	2 (33)	0 (0)	NS	4 (67)	2 (33)	0 (0)	0 (0)	0 (0)	NS
Distal/rectum	48	21 (44)	21 (44)	6 (12)		23 (48)	15 (31)	10 (21)		15 (31)	6 (13)	3 (6)	10 (21)	14 (29)
Tumor grade
Poor	8	5 (62)	3 (38)	0 (0)	NS	5 (63)	2 (25)	1 (12)	NS	4 (50)	1 (13)	0 (0)	1 (13)	2 (25)	NS
Moderate	44	19 (43)	19 (43)	6 (14)		21 (48)	15 (34)	8 (18)		14 (32)	7 (16)	3 (7)	8 (18)	12 (27)
Well	2	1 (50)	1 (50)	0 (0)		1 (50)	0 (0)	1 (50)		1 (50)	0 (0)	0 (0)	1 (50)	0 (0)	NS
Tumor stage
I-II	20	9 (45)	9 (45)	2 (10)	NS	8 (40)	10 (50)	2 (10)	NS	7 (35)	6 (30)	0 (0)	4 (20)	3 (15)	NS
III-IV	34	16 (47)	14 (41)	4 (12)		19 (56)	7 (21)	8 (23)		12 (35)	2 (6)	3 (9)	6 (18)	11(32)

MSI-H: Microsatellite instability-high; MSI-L: Microsatellite instability-low; MSS: Microsatellite stable; NS: Not significant; In paired normal/tumor tissues: H/H: Microsatellite instability-high/microsatellite instability-high; L/L: Microsatellite instability-low/microsatellite instability-low; S/S: Microsatellite stable/microsatellite stable; L/S: Microsatellite instability-low/microsatellite stable; S/L: Microsatellite stable/microsatellite instability-low; L/H: Microsatellite instability-low/microsatellite instability-high; H/L: Microsatellite instability-high/microsatellite instability-low.

Citation: Cabral LKD, Mapua CA, Natividad FF, Sukowati CHC, Cortez ER, Enriquez MLD. MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos. World J Gastrointest Oncol 2021; 13(12): 2101-2113
URL: https://www.wjgnet.com/1948-5204/full/v13/i12/2101.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i12.2101