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©The Author(s) 2021.
World J Gastrointest Oncol. Dec 15, 2021; 13(12): 2101-2113
Published online Dec 15, 2021. doi: 10.4251/wjgo.v13.i12.2101
Published online Dec 15, 2021. doi: 10.4251/wjgo.v13.i12.2101
Table 1 hMLH1 methylation status in the Filipinos colorectal cancer patients
| Normal tissue (%) | Tumor tissue(%) | Normal/tumor (%) | |||||||||
| M | U | M | U | M/M | U/U | M/U or U/M | |||||
| Freq | 19 | 35 | P value | 5 | 49 | P value | 4 | 34 | 16 | P value | |
| Gender | |||||||||||
| Male | 30 | 9 (30) | 21 (70) | NS | 2 (7) | 28 (93) | NS1 | 1 (3) | 20 (67) | 9 (30) | NS |
| Female | 24 | 10 (42) | 14 (58) | 3 (12) | 21 (88) | 3 (13) | 14 (58) | 7 (29) | |||
| Age | |||||||||||
| ≤ 40 | 5 | 3 (60) | 2 (40) | NS1 | 0 (0) | 5 (100) | NS1 | 0 (0) | 2 (40) | 3 (60) | NS |
| > 40 | 49 | 16 (33) | 33 (67) | 5 (10) | 44 (90) | 4 (8) | 32 (65) | 13 (27) | |||
| Location of tumor | |||||||||||
| Proximal | 6 | 4 (67) | 2 (33) | NS1 | 2 (33) | 4 (67) | 0.031 | 2 (33) | 2 (33) | 2 (33) | 0.029 |
| Distal/rectum | 48 | 15 (31) | 33 (69) | 3 (6) | 45 (94) | 2 (4) | 32 (67) | 14 (29) | |||
| Tumor grade | |||||||||||
| Poor | 8 | 5 (62) | 3 (38) | NS | 1 (12) | 7 (88) | NS | 1 (12) | 3 (38) | 4 (50) | NS |
| Moderate | 44 | 13 (30) | 31 (70) | 4 (9) | 40 (91) | 3 (7) | 30 (68) | 11 (25) | |||
| Well | 2 | 1 (50) | 1 (50) | 0 (0) | 2 (100) | 0 (0) | 1 (50) | 1 (50) | |||
| Tumor stage | |||||||||||
| I-II | 20 | 6 (30) | 14 (70) | NS | 2 (10) | 18 (90) | NS1 | 2 (10) | 14 (70) | 4 (20) | NS |
| III-IV | 34 | 13 (38) | 21 (62) | 3 (9) | 31 (91) | 2 (6) | 20 (59) | 12 (35) | |||
- Citation: Cabral LKD, Mapua CA, Natividad FF, Sukowati CHC, Cortez ER, Enriquez MLD. MutL homolog 1 methylation and microsatellite instability in sporadic colorectal tumors among Filipinos. World J Gastrointest Oncol 2021; 13(12): 2101-2113
- URL: https://www.wjgnet.com/1948-5204/full/v13/i12/2101.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v13.i12.2101