Dysbiosis of the duodenal microbiota as a diagnostic marker for pancreaticobiliary cancer

Table 6 Past reports on microbes and pancreaticobiliary cancer

Disease	Ref.	Microbes	Sample	Role
Pancreatic cancer	Michaud et al[30]	A history of periodontal diseases		Risk factor
	Farrell et al[28]	A combination of Neisseria elongate and Streptococcus mitis	Oral	Distinguishing from healthy controls
	Torres et al[29]	Ratio of Leptotrichia to Porphyromonas	Saliva	Higher in pancreatic cancer patients
	Fan et al[27]	Porphyromonas gingivalis	Oral, antibody	Risk factor
	Olson et al[39]	Firmicutes	Oral	More abundant
	Lu et al[40]	Leptotrichia, Fusobacterium, Rothia, Actinomyces, Corynebacterium, Atopobium, Peptostreptococcus, Catonella, Oribacterium, Filifactor, Campylobacter, Moraxella, Tannerella	Tongue coating	More prevalent
	Mei et al[46]	Acinetobactor, Aquabacterium, Oceanobacillus, Rahnella, Massilia, Delftia, Deinococcus, Sphingobium	Duodenal mucosa	More abundant
	Mitsuhashi et al[43]	Fusobacterium species	Cancer tissue	Poor prognosis
	Riquelme et al[44]	Pseudoxanthomonas, Streptomyces, Saccharopolyspora, Bacillus clausii	Cancer tissue	Long-term survival
Pancreatic and ampullary cancer	Di Calro et al[45]	Escherichia coli, Klebsiella pneumoniae	Bile juice	Predictor for survival
IPMN with high-grade dysplasia	Gaiser et al[47]	Granulicatella adiacens, Fusobacterium nucleatum	Cyst fluid	More abundant

IPMN: Intraductal papillary mucinous neoplasm.