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©The Author(s) 2021.
World J Gastrointest Oncol. Nov 15, 2021; 13(11): 1766-1780
Published online Nov 15, 2021. doi: 10.4251/wjgo.v13.i11.1766
Published online Nov 15, 2021. doi: 10.4251/wjgo.v13.i11.1766
TGFBR2 -875G/A (rs3087465) | Advanced CRC, n (%) | Healthy controls, n (%) | OR (95%CI) | P value |
Total n | 96 (52.2) | 307 (100) | ||
GG | 64 (66.7) | 193 (62.9) | Reference | |
GA | 29 (30.2) | 102 (33.2) | 0.857 (0.520-1.414) | 0.546 |
AA | 3 (3.1) | 12(3.9) | 0.754 (0.206-2.756) | 0.668 |
c 0.940 | ||||
GA + AA | 32 (33.3) | 114 | 0.846 (0.522-1.373) | 0.499 |
GA vs GG + AA | 29 vs 67 | 102 vs 205 | 0.870 (0.530-1.429) | 0.582 |
G allele | 157 (81.8) | 488 (79.5) | Reference | |
A allele | 35 (18.2) | 126 (20.5) | 0.863 (0.570÷1.308) | 0.488 |
Female | 35 (36.5) | 240 | ||
GG | 22 (62.9) | 159 (66.3) | Reference | |
GA | 12 (34.3) | 72 (30) | 1.205 (0.565-2.567) | 0.629 |
AA | 1 (2.9) | 9 (3.7) | 0.803 (0.097-6.647) | 0.839 |
c 1.000 | ||||
GA + AA | 13 (37.1) | 81 (33.8) | 1.160 (0.556-2.421) | 0.693 |
G allele | 56 (80) | 390 (81.3) | Reference | |
A allele | 14 (20) | 90 (18.7) | 1.083 (0.578-2.032) | 0.803 |
Male | 61 (63.5) | 67 | ||
GG | 42 (68.9) | 34 (50.7) | Reference | |
GA | 17 (27.9) | 30 (44.8) | 0.459 (0.217-0.969) | 0.039 |
AA | 2 (3.3) | 3 (4.5) | 0.540 (0.085-3.417) | 0.507 |
c 0.841 | ||||
GA + AA | 19 (31.1) | 33 (49.3) | 0.466 (0.226-0.961) | 0.037 |
GG vs GA + AA | 42 vs 19 | 34 vs 33 | 2.146 (1.041-4.422) | 0.037 |
GA vs GG + AA | 17 vs 44 | 30 vs 37 | 0.477 (0.228-0.997) | 0.047 |
G allele | 101 (82.8) | 98 (73.1) | Reference | |
A allele | 21 (17.2) | 36 (26.9) | 0.566 (0.309-1.037) | 0.064 |
- Citation: Stanilov N, Grigorova A, Velikova T, Stanilova SA. Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men. World J Gastrointest Oncol 2021; 13(11): 1766-1780
- URL: https://www.wjgnet.com/1948-5204/full/v13/i11/1766.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v13.i11.1766