Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men

Table 3 TGFBR2G^[-875]A rs3087465 polymorphism distribution in early CRC cases compared to healthy controls

TGFBR2 -875G/A (rs3087465)	Early CRC, n (%)	Healthy controls, n (%)	OR (95%CI)	P value
Total n	88 (47.8)	307 (100)
GG	53 (60.2)	193 (62.9)	Reference
GA	29 (33)	102 (33.2)	1.035 (0.620-1.728)	0.894
AA	6 (6.8)	12 (3.9)	1.821 (0.653-5.080)	0.246
GA + AA	35 (39.8)	114	1.118 (0.688-1.817)	0.652
G allele	135 (76.7)	488 (79.5)	Reference
A allele	41 (23.3)	126 (20.5)	1.176 (0.788-1.756)	0.427
Female	34 (38.6)	240
GG	20 (58.8)	159 (66.3)	Reference
GA	10 (29.4)	72 (30)	1.104 (0.492-2.478)	0.810
AA	4 (11.8)	9 (3.7)	3.533 (0.996-12.535)	0.039
				c 0.103
GA + AA	14 (41.2)	81 (33.8)	1.374 (0.660-2.861)	0.394
G allele	50 (73.5)	390 (81.3)	Reference
A allele	18 (26.5)	90 (18.7)	1.560 (0.869-2.802)	0.134
Male	54 (61.4)	67
GG	33 (61.1)	34 (50.7)	Reference
GA	19 (35.2)	30 (44.8)	0.653 (0.309-1.379)	0.262
AA	2 (3.7)	3 (4.5)	0.687 (0.108-4.378)	0.690
				c 1.000
GA + AA	21 (38.9)	33 (49.3)	0.656 (0.317-1.357)	0.254
GG vs GA + AA	33 vs 21	34 vs 33	1.525 (0.737-3.156)	0.254
G allele	85 (78.7)	98 (73.1)	Reference
A allele	23 (21.3)	36 (26.9)	0.737 (0.405-1.340)	0.316

c: Corrected; CRC: Colorectal cancer.