Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men

Table 2 Genotype distributions and allele frequencies of TGFBR2 rs3087465 polymorphism in the case group divided into advanced and early colorectal cancer groups (and females and males, respectively)

TGFBR2 -875G/A (rs3087465)	Advanced CRC, n (%)	Early CRC, n (%)	OR (95%CI)	P value
Total n	96 (52.2)	88 (47.8)
GG	64 (66.7)	53 (60.2)	Reference
GA	29 (30.2)	29 (33)	0.828 (0.441-1.556)	0.557
AA	3 (3.1)	6 (6.8)	0.414 (0.099-1.735)	0.216
				c 0.373
GA + AA	32 (33.3)	35 (39.8)	0.757 (0.415-1.382)	0.365
G allele	157 (81.8)	135 (76.7)	Reference
A allele	35 (18.2)	41 (23.3)	0.734 (0.442-1.218)	0.230
Female	35 (36.5)	34 (38.6)
GG	22 (62.9)	20 (58.8)	Reference
GA	12 (34.3)	10 (29.4)	1.091 (0.388-3.071)	0.869
AA	1 (2.9)	4 (11.8)	0.227 (0.023-2.207)	0.171
				c 0.370
GA + AA	13 (37.1)	14 (41.2)	0.844 (0.321-2.222)	0.731
G allele	56 (80)	50 (73.5)	Reference
A allele	14 (20)	18 (26.5)	0.694 (0.313-1.539)	0.368
Male	61 (63.5)	54 (61.4)
GG	42 (68.9)	33 (61.1)	Reference
GA	17 (27.9)	19 (35.2)	0.703 (0.317-1.561)	0.386
AA	2 (3.3)	2 (3.7)	0.786 (0.105-5.878)	0.814
				c 1.000
GA + AA	19 (31.1)	21 (38.9)	0.711 (0.329÷1.535)	0.384
GG vs GA + AA	42 vs 19	33 vs 21	1.407 (0.651-3.038)	0.384
G allele	101 (82.8)	85 (78.7)	Reference
A allele	21 (17.2)	23 (21.3)	0.768 (0.398÷1.484)	0.432

c: Corrected; CRC: Colorectal cancer.