Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men

Table 1 Difference in genotype distribution and allele frequencies of TGFBR2 rs3087465 polymorphism between the case (colorectal cancer patients) and control (healthy persons) groups, females and males, respectively

Genotype	CRC, n (%)	Healthy controls, n (%)	OR (95%CI)	P value
n	184 (100)	307 (100)
GG	117 (63.6)	193 (62.9)	Reference
GA	58 (31.5)	102 (33.2)	0.938 (0.631-1.393)	0.751
AA	9 (4.9)	12 (3.9)	1.237 (0.506-3.026)	0.640
GA + AA	67 (36.4)	114	0.969 (0.664-1.416)	0.873
G allele	292 (79.3)	488 (79.5)	Reference
A allele	76 (20.7)	126 (20.5)	1.008 (0.732-1.387)	0.961
Female	69	240
GG	42 (40.9)	159 (66.3)	Reference
GA	22 (31.9)	72 (30)	1.157 (0.664-2.079)	0.626
AA	5 (7.2)	9 (3.7)	2.103 (0.669-6.608)	0.195
GA + AA	27(39.1)	81 (33.8)	1.262 (0.726-2.193)	0.409
GG vs GA + AA	42 vs 27	159 vs 81	0.792 (0.456-1.377)	0.409
GA vs GG + AA	22 vs 47	72 vs 168	1.092 (0.614-1.944)	0.764
G allele	106 (76.8)	390 (81.3)	Reference
A allele	32 (23.2)	90 (18.7)	1.346 (0.794-2.281)	0.269
Male	115	67
GG	75 (65.2)	34 (50.7)	Reference
GA	36 (31.3)	30 (44.8)	0.544 (0.289-1.023)	0.058
AA	4 (3.5)	3 (4.5)	0.604 (0.128-2.850)	0.521
				c 0.823
GA + AA	40 (34.8)	33 (49.3)	0.549 (0.297-1.015)	0.055
GG vs GA + AA	75 vs 40	34 vs 33	1.820 (0.985-3.362)	0.055
GA vs GG + AA	36 vs 79	30 vs 37	0.562 (0.302-1.047)	0.068
G allele	186 (80.9)	98 (73.1)	Reference
A allele	44 (19.1)	36 (26.9)	0.644 (0.389-1.066)	0.086

c: Corrected; CRC: Colorectal cancer.