Direct interaction between Rab5a and Rab4a enhanced epidermal growth factor-stimulated proliferation of gastric cancer cells

Table 2 Expression levels of Rab5a, Rab4a, leucine zipper motif 1, and histone deacetylase 1 in normal gastric mucosa, gastric tissues adjacent to the tumors, early-stage gastric cancer tumor tissues, and advanced-stage gastric cancer tissues as determined by immunochemical analysis

	HDAC1				APPL1				Rab4a				Rab5a
	-	+	++	+++	-	+	++	+++	-	+	++	+++	-	+	++	+++
Normal gastric tissue	20	0	0	0	12	8	0	0	18	2	0	0	16	4	0	0
Paracancerous tissue	24	10	0	0	24	10	0	0	20	14	0	0	22	12	0	0
Early-stage gastric cancer	4	8	8	0	5	10	5	0	6	12	2	0	8	10	2	0
Advanced-stage gastric cancer	0	8	10	4	2	6	10	4	0	6	12	4	2	6	10	4
Statistics (χ2)	59.162				43.456				58.338				45.719
P value	< 0.001				< 0.001				< 0.001				< 0.001

Statistical analysis of expression levels of Rab5a, Rab4a, leucine zipper motif 1, histone deacetylase 1 between four groups of normal, paracancerous, early-stage gastric cancer, and advanced-stage gastric cancer tissues by Kruskal-Wallis H Test. HDAC1: Histone deacetylase 1; APPL1: Leucine zipper motif 1.