Radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma

Table 3 Studies of radiotherapy for gastric mucosa-associated lymphoid tissue lymphoma

Ref.	Country	Patients, n (%)	Stage	Failure of H. pylori eradication or H. pylori	H. pylori	Median [Total RT dose]	Median F/U (mo)	Survival	Relapse (Local/distant)	Toxicity G3+
Schechter et al[31], 1998	NY, United States	17	IE = 71%; II1 = 24%, II2 = 5%	17/17	12/17	30 Gy [28.5–43.5]	27 [11–68]	NR	0/0	0
Park et al[32], 2002	Korea	6	IE = 100%	4/6	1/6	30.6 Gy [30–39]	12	100%	0/0	0
Tsang et al[33], 2003	Canada	13/93 (gastric and RT subgroup)	IA = 88%; IIA = 10%, IIB = 2%	13/13	7/15	26.2 [20–35]	61	98% at 5 yr for the entire cohort	0/0	0
Koch et al[24], 2005	Germany	144/332 (indolent subgroup with conservative management)	I = 66%; II1 = 17%; II2 = 17%	NR	NR	40 Gy	42 [0.07–97.4]	93% at 3.5 yr	6	9
Avilés et al[34], 2005	Mexcio	78/241 (RT group)	IE = 73%; IIE = 27%	NR	NR	40 Gy	90 [58–139]	75% at 10 yr	0/30	0
Sugimoto et al[35], 2006	Japan	3	I = 3	3/3	0	39 Gy [36–40]	42 [24–72]	100%	0/0	0
Tsai et al[36], 2007	MA, United Sttaes	18/77 gastric and RT subgroup	IE = 100%	6/18	NR	30 Gy [18–40]	61 [2–177]	91% at 5 yr for the entire cohort	0 over 11 patients treated by RT	NR
Yamashita et al[37], 2008	Japan	11/41 gastric subgroup	IE = 90%; IIE = 10% (whole cohort)	6/11	5/11	30 Gy	32 [2–162]	100%	0/0	0
Vrieling et al[38], 2008	The Netherlands	68/115 (RT subgroup)	I = 79%; II1 = 12%, II2 = 9%	85/115	13/115	40 Gy [31–44]	150 [7–301] (radiotherapy only cohort)	78% at 5 yr (entire cohort)	3/4	NR
Gobbi et al[39], 2009	Italia	5	IE = 4; IIE = 1	5/5	0/5	30 Gy	48 [21–70]	80%	0	0
Tomita et al[40], 2009	Japan	20/50 (gastric subgroup)	IE = 96%; IIE = 4% (entire cohort)	20/20	7/20	32 Gy [25.6–50]	92	97% at 5 yr (entire cohort)	0	2% for all cohort
Goda et al[41], 2010	Canada	25/167 (gastric subgroup)	IA = 90%; IIA = 9%; IIB = 1%	19/19	5/19	30 Gy [20-35]	89 [8–194]	95% at 5-yr (entire cohort)	0	NR
Okada et al[42], 2012	Japan	22	IE = 19; IIE = 3	22/22	14/22	30 Gy	74 [27–159]	91% at 5-yr	0/3	0
Kim et al[43]; 2013	Korea	64	IE = 53 (83%); IIE = 11 (17%)	56/60	33/64	36 Gy	39 [9–131]	94% at 5-yr	5	0
Wirth et al[16], 2013	International (IELSG)	102	IE = 84%; IIE = 16%	80/102	45/90	40 Gy [26–46]	95 [4–528]	70% at 10 yr	7/5	NR
Nam et al[44], 2014	Korea	41 (MALT subgroup)	IE = 77%; IIE = 23%	29/41	29.6%(whole cohort)	30.6 Gy [30.6-43.2]	48 [6– 158]	90% at 5-yr (entire cohort)	1/0	0
Abe et al[45], 2013	Japan	34	IE = 34 (100%)	34/34	17/34	30 Gy	90 (14–156)	100% at 5-yr	1 (emergency gastrectomy during RT at 15 Gy for acute bleeding)/0	1
Ruskoné-Fourmestraux et al[18], 2015	France	53	IE = 45 (85%); IIE = 8 (15%)	53/53	15/53	30 Gy	59 (4–199)	94% at 5-yr	0/0	0
Lim et al[46], 2016	Korea	33	IE = 30 (91%); IIE = 3 (9%)	33/33	17/33	30.6 Gy	50 (12–145)	97% at 5-yr	0	0
Ohkubo et al[47], 2017	Japan	27	IE = 27 (100%)	24/27	15/27	30 Gy [30–39.5]	121 (8–176)	92% at 5-yr; 87% at 10-yr	0/2	2/27 (White blood cell count decreases)
Teckie et al[48], 2017	NY, United States	122/225 (gastric and RT subgroup)	IE = 225 (92%); IIE = 19 (8%)	115/122	78/122	30 Gy	62 [2–256]	92% at 5-yr; 79% at 10-yr for all the subgroups	7 (gastric subgroup)	NR
Pinnix et al[17], 2019	TX, United States	32	IE = 25(78%); IIE = 5 (16%); IV = 2 (6%)	32/32	25/32	36 Gy (2; 6%); 30 Gy (n = 19; 59%); 24 Gy (n = 11; 34%)	55 [32–78]	97% at 2-yr	1/1	NR
Schmelz et al[49], 2019	Germany	22	IE = 20; IIE = 2	22/22	0/22	25.2 Gy/36 Gy	79 [36.4 –143.8]	100% at 56.6 yr	0	NR
Watanabe et al[50], 2020	Japan	30/34 (gastric subgroup)	IE = 100%	26/30	16/30	30 Gy [30–40]	61 [9–136]	94.7% at 5 yr	0/2	0

RT: Radiotherapy; NR: Not reported; H. pylori: Helicobacter pylori.