Lateral pelvic lymph nodes for rectal cancer: A review of diagnosis and management

Table 3 Variables in complications of lateral pelvic lymph node dissection in recent meta-analyses and systematic reviews

Ref.	Study (RCT)	Treatment	Patients	CRT or RT	Operation time	Blood loss	Complications	Urinary dysfunction	Sexual dysfunction
Gao et al[63], 2020	12 (6)	TME + LPLD	1952	359	WMD 97.03 min, 95%CI: 75.35-118.72, P < 0.001	WMD 303.20 mL, 95%CI: 156.82-449.58, P < 0.001	RR 1.35, 95%CI: 1.05-1.74, P = 0.02	Pooled RR 1.44, 95%CI: 0.63-3.28, P = 0.38	Pooled RR 1.41, 95%CI: 0.87-2.31, P = 0.17
		TME	2506	1009
Wang et al[64], 2020	16 (4)	TME + LPLD	2984				OR 1.48, 95%CI: 1.07-2.03, P = 0.02	OR 1.60, 95%CI: 0.66-3.87, P = 0.3
		TME	3397
Ma et al[65], 2020	26 (5)	TME + LPLD	417	417	WMD 92.50 min, 95%CI: 75.63-109.37	WMD 283.89 mL, 95%CI: 183.00-384.79	OR 1.30, 95%CI: 1.04-1.63	OR 2.14, 95%CI: 1.21-3.79, P = 0.009	OR 4.19, 95%CI: 1.55-11.33, P = 0.005
		TME	1102	1102
Emile et al[66], 2020	29 (5)	TME + LPLD	4194	551	360 min (median), range 310-540, P = 0.02	582 mL (median), P = 0.4	OR 1.48, 95%CI: 1.18-1.87, P < 0.001	OR 2.1, 95%CI: 1.21-3.67, P = 0.008	OR 1.62, 95%CI: 0.94-2.79, P = 0.08
		TME	6452	1467	294.7 min (median) range 206-480	337 mL (median)
Hajibandeh et al[67], 2020	18 (2)	TME + LPLD	2762	321	MD 116.02, 95%CI: 89.20-142.83, P < 0.00001		OS 1.59, 95%CI: 1.14-2.24, P = 0.007	OR 6.66, 95%CI: 3.31-13.39, P < 0.00001	OR 9.67, 95%CI 2.38-39.26, P = 0.002
		TME	3371	735
Yang et al[69], 2020	8 (1)	CRT + TME + LPLD	435	435
		CRT + TME	1461	1461	MD −138.63 min, 95%CI: −219.66--57.60, P < 0.01	MD −226.24 mL, 95%CI: −505.76-53.27, P = 0.11		OR 0.20, 95%CI: 0.08-0.48, P < 0.01

CI: Confidence interval; CRT: Chemoradiation therapy; LPLD: Lateral pelvic lymph node dissection; MD: Mean difference; OR: Odds ratio; RCT: Randomized controlled trial; RR: Risk ratio; RT: Radiation therapy; TME: Total mesorectal excision; WMD: Weighted mean difference.