Gallbladder cancer: Historical treatment and new management options

Table 3 Cancer stage grouping

Stage	T	N	M	Description
0	Tis	N0	M0	Cancer in situ
I	T1	N0	M0	Tumor is only in the gallbladder and has not spread
II	T2	N0	M0	Tumor has extended to the perimuscular connective tissue but has not spread elsewhere
IIIA	T3	N0	M0	Tumor has spread beyond the gallbladder but not to nearby arteries or veins. It has not spread to any lymph nodes or other parts of the body
IIIB	T1-3	N1	M0	Tumor of any size has spread to nearby lymph nodes but not to nearby arteries and/or veins or to other parts of the body
IVA	T4	N0 or N1	M0	Tumor has spread to nearby arteries, veins, and/or nearby lymph nodes, but it has not spread to other parts of the body
IVB	Any T	Any N	M1	Any tumor that has spread to other parts of the body
	Any T	N2	M0	Any tumor that has distant lymph node spread, even if it has not spread to distant organs