Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review

doi:10.4251/wjgo.v13.i1.1

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 13, Issue 1

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6441)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-2) series.

Item

Count

PDF

330

WORD

209

HTML

3099

Figures (1-1)

458

Tables (1-2)

287

Sum=4383

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

464

Download

500

Sum=964

Publishing Process of This Article

Item

Count

Browse

417

Download

677

Sum=1094

Jan 15, 2021 (publication date) through Jul 22, 2024

Times Cited of This Article

Times Cited (12)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Therapeutic and Diagnostic Guidelines

World J Gastrointest Oncol. Jan 15, 2021; 13(1): 1-11
Published online Jan 15, 2021. doi: 10.4251/wjgo.v13.i1.1

Table 1 Two main categories of myeloid-derived suppressor cells and their immunosuppressive functions[59]

Type of MDSC	Markers in humans	Immunosuppression mediator	Mechanism of immunosuppression
PMN-MDSCs	CD11b⁺CD14⁻CD15⁺HLADR⁻or CD11b⁺CD14⁻CD66b⁺ or LOX-1⁺	ARG1, ROS	Suppressing immune responses mainly in an antigen-specific manner; ROS production
M-MDSCs	CD11b⁺CD14⁺CD15⁻HLADR^low/−	NO, ARG1, and cytokines such as TGF-β and IL-10	Suppressing T cell responses, both in antigen-specific and non-specific manners; production of NO and cytokines

ARG1: Arginase 1; IL-10: Interleukin-10; M-MDSCs: Monocytic myeloid-derived suppressor cells; NO: Nitric oxide; PMN-MDSCs: Polymorphonuclear myeloid-derived suppressor cells; ROS: Reactive oxygen species; TGF-β: Transforming growth factor-beta; MDSC: Myeloid-derived suppressor cell.

Citation: Farshidpour M, Ahmed M, Junna S, Merchant JL. Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review. World J Gastrointest Oncol 2021; 13(1): 1-11
URL: https://www.wjgnet.com/1948-5204/full/v13/i1/1.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i1.1