Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review

doi:10.4251/wjgo.v13.i1.1

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Jan 15, 2021 (publication date) through Jan 11, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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World J Gastrointest Oncol. Jan 15, 2021; 13(1): 1-11
Published online Jan 15, 2021. doi: 10.4251/wjgo.v13.i1.1

Table 1 Two main categories of myeloid-derived suppressor cells and their immunosuppressive functions[59]

Type of MDSC	Markers in humans	Immunosuppression mediator	Mechanism of immunosuppression
PMN-MDSCs	CD11b⁺CD14⁻CD15⁺HLADR⁻or CD11b⁺CD14⁻CD66b⁺ or LOX-1⁺	ARG1, ROS	Suppressing immune responses mainly in an antigen-specific manner; ROS production
M-MDSCs	CD11b⁺CD14⁺CD15⁻HLADR^low/−	NO, ARG1, and cytokines such as TGF-β and IL-10	Suppressing T cell responses, both in antigen-specific and non-specific manners; production of NO and cytokines

ARG1: Arginase 1; IL-10: Interleukin-10; M-MDSCs: Monocytic myeloid-derived suppressor cells; NO: Nitric oxide; PMN-MDSCs: Polymorphonuclear myeloid-derived suppressor cells; ROS: Reactive oxygen species; TGF-β: Transforming growth factor-beta; MDSC: Myeloid-derived suppressor cell.

Citation: Farshidpour M, Ahmed M, Junna S, Merchant JL. Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review. World J Gastrointest Oncol 2021; 13(1): 1-11
URL: https://www.wjgnet.com/1948-5204/full/v13/i1/1.htm
DOI: https://dx.doi.org/10.4251/wjgo.v13.i1.1