Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts

Table 5 Area under the curve for diagnosis of mucinous and malignant cysts

Variables	Mucinous cysts				Malignant cysts
	AUC	P value	Confidence interval		AUC	P value	Confidence interval
			Lower limit	Upper limit			Lower limit	Upper limit
CEA in mg/dL	0.889	0.002	0.720	1.000	0.812	0.038	0.579	1.000
Cytology	0.598	0.443	0.349	0.847	0.771	0.072	0.571	0.970
Mutation (KRAS/GNAS)	0.833	0.009	0.634	1.000	0.841	0.023	0.615	1.000
Met_NESP55	0.620	0.35	0.370	0.869	0.759	0.085	0.481	1.000
Met_AS	0.590	0.483	0.339	0.841	0.741	0.108	0.461	1.000
Met_XL	0.474	0.841	0.228	0.721	0.629	0.389	0.357	0.902
Met_1A	0.513	0.92	0.262	0.764	0.565	0.667	0.261	0.868
GNAS locus methylation changes	0.645	0.256	0.400	0.891	0.971	0.002	0.901	1.000

AUC: Area under the curve; CEA: Carcinoembryonic antigen; GNAS: Guanine nucleotide-binding protein, alpha stimulating; Met: Methylation changes.