Interleukin-1 receptor antagonist enhances chemosensitivity to fluorouracil in treatment of Kras mutant colon cancer

Figure 4 Interleukin-1 RA could counteract the abnormally high expression of P-TAK1, P-P65, and P-MEK caused by fluorouracil in the SW620 cell line. A: Western blot assay showed that the abnormally high expression of P-TAK1, P-P65 and P-MEK caused by fluorouracil (5-FU) was decreased by interleukin (IL)-1 RA treatment in the SW620 cell line; B: The abnormally high expression of P-TAK1 in the SW620 cell line caused by 5-FU was significantly decreased in the 5-FU and IL-1 RA group (SW620: 5-FU vs the control, ^aP = 0.0199; 5-FU and IL-1RA vs 5-FU, ^bP = 0.0269); C: The abnormally high expression of P-P65 in the SW620 cell line caused by 5-FU was significantly decreased in the 5-FU and IL-1 RA group (SW620: 5-FU vs the control, ^aP = 0.0048; IL-1RA vs 5-FU, ^bP = 0.0040); D: The abnormally high expression of P-MEK in the SW620 cell line caused by 5-FU was significantly decreased in the 5-FU and IL-1 RA group (SW620: 5-FU vs the control, ^aP = 0.0019; IL-1RA vs 5-FU, ^bP = 0.0201).