Interleukin-1 receptor antagonist enhances chemosensitivity to fluorouracil in treatment of Kras mutant colon cancer

Figure 2 Expression of interleukins in the activated nuclear factor kappa-B pathway in SW620 cells. A and B: Reverse transcription-polymerase chain reaction (RT-PCR) assay showed that the expression of interleukin (IL)-1α and IL-1β was significantly higher in SW620 cells than in NCM460 cells (IL-1α: SW620 vs NCM460, ^aP = 0.0003; IL-1β: SW620 vs NCM460, ^aP = 0.0001); C-G: RT-PCR assay showed that the expression of IL-6, IL-8, IL-17, IL-21, and TLR4 was significantly higher in SW620 cells than in NCM460 cells (IL-6: SW620 vs NCM460, ^aP = 0.0005; IL-8: SW620 vs NCM460, ^aP = 0.0007; IL-17: SW620 vs NCM460, ^aP < 0.0001; IL-21: SW620 vs NCM460, ^aP < 0.0001; TLR4-6 : SW620 vs NCM460, ^aP < 0.0001).