Review
Copyright ©The Author(s) 2020.
World J Gastrointest Oncol. Aug 15, 2020; 12(8): 791-807
Published online Aug 15, 2020. doi: 10.4251/wjgo.v12.i8.791
Table 1 World Health Organization classification of gastrointestinal neuroendocrine tumors
Well-differentiated neuroendocrine neoplasms (NENs)
Ki-67 index (%)Mitotic index/10 HPF
NET grade 1 (G1)< 3< 2
NET grade 2 (G2)3-202-20
NET grade 3 (G3)> 20> 20
Poorly differentiated neuroendocrine neoplasms (NENs)
Ki-67 index (%)Mitotic index/10 HPF
NEC grade 3>20>20
-Small cell type
-Large cell type
Mixed neuroendocrine neoplasms (MiNEN)
Source: Adapted from WHO Classification of Tumors of Endocrine Organs, Fourth edition (2017)[14]