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©The Author(s) 2020.
World J Gastrointest Oncol. Jul 15, 2020; 12(7): 741-755
Published online Jul 15, 2020. doi: 10.4251/wjgo.v12.i7.741
Published online Jul 15, 2020. doi: 10.4251/wjgo.v12.i7.741
Table 5 Correlation between the immunohistochemical biomarkers Maspin and p53 expression, in relation to TP53 gene status
| Immunohistochemical parameter | Number (n = 266) | aP53 nuclear expression (n = 266) | aP value | bTP53 gene status (n = 266) | bP value | |||||
| Negative (n = 40) | 10%-50% (n = 69) | > 50% (n = 157) | Wild-type (n = 176) | Mutated (n = 90) | ||||||
| Maspin expression - tumor core | Negative | 39 | 5 | 7 | 27 | > 0.05 | 26 (14.77) | 13 (14.44) | 0.05 | |
| Cytoplasm | 125 | 19 | 34 | 72 | 74 (42.05) | 51 (56.67) | ||||
| Nucleus | 17 | 7 | 5 | 5 | 15 (8.52) | 2 (2.22) | ||||
| Mixed | 85 | 9 | 23 | 53 | 61 (34.66) | 24 (26.67) | ||||
| Maspin expression - invasion front | Negative | 21 | 9 | 3 | 9 | > 0.05 | 8 (4.55) | 13 (14.44) | < 0.01 | |
| Nucleus | 44 | 14 | 16 | 14 | 35 (19.88) | 9 (10) | ||||
| Mixed | 201 | 17 | 50 | 134 | 133 (75.57) | 68 (75.56) | ||||
| p53– nuclear expression | Negative | 40 | - | - | - | 30 (17.04) | 10 (11.11) | > 0.05 | ||
| 5%-50% | 69 | 47 (26.71) | 22 (24.44) | |||||||
| > 50% | 157 | 99 (56.25) | 58 (64.45) | |||||||
- Citation: Gurzu S, Jung I, Sugimura H, Stefan-van Staden RI, Yamada H, Natsume H, Iwashita Y, Szodorai R, Szederjesi J. Maspin subcellular expression in wild-type and mutant TP53 gastric cancers. World J Gastrointest Oncol 2020; 12(7): 741-755
- URL: https://www.wjgnet.com/1948-5204/full/v12/i7/741.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v12.i7.741