Timing of surgery after neoadjuvant chemoradiotherapy affects oncologic outcomes in patients with esophageal cancer

doi:10.4251/wjgo.v12.i6.687

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World Journal of Gastrointestinal Oncology

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Meta-Analysis

World J Gastrointest Oncol. Jun 15, 2020; 12(6): 687-698
Published online Jun 15, 2020. doi: 10.4251/wjgo.v12.i6.687

Table 2 Meta-analysis and subgroup analyses

Analysis	n	Ref.	Random-effects model		Fixed-effects model		Heterogeneity
Analysis	n	Ref.	HR (95%CI)	P value	HR (95%CI)	P value	I²	Ph
Esophageal cancer OS	16	[5,7-11,13,16-24]	1.107 (1.014-1.208)	0.023	1.089 (1.036-1.145)	0.001^a	48.80%	0.015
DFS	3	[17,21,23]	1.300 (0.883-1.913)	0.184	1.263 (0.976-1.633)	0.075	48.40%	0.144
Subgroup 1: Study design	16	[5,7-11,13,16-24]	1.107 (1.014-1.208)	0.196	1.089 (1.036-1.145)	0.196	0.00	0.865
Prospective	9	[5,8,16-18,20-22,24]	1.073 (0.964-1.194)	0.064	1.073 (0.964-1.194)	0.002^a	76.30%	0.000
Retrospective	7	[7,9-11,13,19,23]	1.150 (0.992-1.332)	0.023^a	1.094 (1.034-1.158)	0.001^a	48.80%	0.015
Subgroup 2: Samplesize	16	[5,7-11,13,16-24]	1.107 (1.014-1.208)	0.023^a	1.089 (1.036-1.145)	0.001^a	48.80%	0.015
< 200	5	[16,19,21-23]	1.294 (0.946-1.771)	0.107	1.254 (0.985-1.597)	0.067	34.70%	0.190
≥ 200	11	[5,7-11,13,17,18,20,24]	1.089 (0.995-1.190)	0.063	1.082 (1.028-1.139)	0.002^a	54.20%	0.016
Subgroup 3: Ethnicity	16	[5,7-11,13,16-24]	1.107 (1.014-1.208)	0.064	1.107 (1.014-1.208)	0.064	48.80%	0.015
Caucasian	12	[5,7-9,11,13,16-19,21,24]	1.091 (0.995-1.197)	0.150	1.091 (0.995-1.197)	0.150	49.30%	0.027
Asian	4	[10,20,22,23]	1.251 (0.922-1.696)	0.023^a	1.251 (0.922-1.696)	0.023^a	57.60%	0.069
Subgroup 4: HR type	16	[5,7-11,13,16-24]	1.107 (1.014-1.208)	0.023^a	1.089 (1.036-1.145)	0.001^a	48.80%	0.015
Univariate	13	[5,8,10,13,16-24]	1.053 (0.952-1.166)	0.314	1.029 (0.949-1.115)	0.492	23.20%	0.209
Multivariate	3	[7,9,11]	1.194 (1.010-1.411)	0.037^a	1.130 (1.059-1.204)	0.000^a	81.00%	0.005
Squamous cell carcinoma OS	6	[10,13,16,20,22,23]	1.096 (0.896-1.341)	0.371	1.009 (0.908-1.120)	0.874	57.20%	0.039
Adenocarcinoma OS	2	[9,21]	1.360 (1.111-1.664)	0.003^a	1.385 (1.186-1.616)	0.000^a	22.00%	0.257

^aStatistical significance. n: Number of studies; HR: Hazard ratio; 95%CI: 95% confidence interval; Ph: P values of Q test for heterogeneity test; OS: Overall survival; DFS: Disease free survival.

Citation: Shang QX, Yang YS, Gu YM, Zeng XX, Zhang HL, Hu WP, Wang WP, Chen LQ, Yuan Y. Timing of surgery after neoadjuvant chemoradiotherapy affects oncologic outcomes in patients with esophageal cancer. World J Gastrointest Oncol 2020; 12(6): 687-698
URL: https://www.wjgnet.com/1948-5204/full/v12/i6/687.htm
DOI: https://dx.doi.org/10.4251/wjgo.v12.i6.687