Characterization and strong risk association of TLR2 del -196 to -174 polymorphism and Helicobacter pylori and their influence on mRNA expression in gastric cancer

Table 4 Genotype frequencies of TLR2 -196 to -174 ins/del and TLR2 19216T/C polymorphisms in Helicobacter pylori-positive and Helicobacter pylori-negative groups, n (%)

Polymorphisms	Models	Genotypes/ alleles	Case
			H. pylori-positive, n = 619	H. pylori-negative, n = 233	OR (95%CI)	P value
TLR2 -196 to -174 ins/del (rs111200466)	Codominant	ins/ins	481 (77.7)	159 (68.2)	1.00	0.0120
		ins/del	127 (20.5)	65 (27.9)	1.55 (1.09-2.19)
		del/del	11 (1.8)	9 (3.9)	2.48 (1.01-6.08)
	Dominant	ins/ins	481 (77.7)	159 (68.2)	1.00	0.0051
		ins/del	138 (22.3)	74 (31.8)	1.62 (1.16-2.27)
		del/del
	Recessive	ins/ins	608 (98.2)	224 (96.1)	1.00	0.0880
		ins/del
		del/del	11 (1.8)	9 (3.9)	2.22 (0.91-5.43)
	Overdo-minant	ins/ins	492 (79.5)	168 (72.1)	1.00	0.0240
		del/del
		ins/del	127 (20.5)	65 (27.9)	1.50 (1.06-2.12)
	Log-additive	---	---	---	1.56 (1.17-2.08)	0.0030
TLR2 19216T/C (rs3804099)	Codominant	T/T	261 (42.2)	128 (54.9)	1.00	0.0039
		T/C	281 (45.4)	83 (35.6)	0.60 (0.44-0.83)
		C/C	77 (12.4)	22 (9.4)	0.58 (0.35-0.98)
	Dominant	T/T	261 (42.2)	128 (54.9)	1.00	< 0.0001
		T/C – C/C	358 (57.8)	105 (45.1)	0.60 (0.44-0.81)
	Recessive	T/T – T/C	542 (87.6)	211 (90.6)	1.00	0.2200
		C/C	77 (12.4)	22 (9.4)	0.73 (0.45-1.21)
	Overdo-minant	T/T – C/C	338 (54.6)	150 (64.4)	1.00	0.0097
		T/C	281 (45.4)	83 (35.6)	0.67 (0.49-0.91)
	Log-additive	---	---	---	0.70 (0.55-0.88)	0.0021

H. pylori: Helicobacter pylori.