Characterization and strong risk association of TLR2 del -196 to -174 polymorphism and Helicobacter pylori and their influence on mRNA expression in gastric cancer

Table 3 Genotype frequencies of TLR2 -196 to -174 ins/del and TLR2 19216 T/C polymorphisms in both case and control groups (GC vs C, CG vs C and GC vs CG) , n (%)

Polymorphisms	Models	Genotypes	C, n = 381	Case
				GC			CG			GC x CG
				n = 202	OR (95%CI)	P value	n = 269	OR (95%CI)	P value	OR (95%CI)	P value
TLR2 -196 to -174 ins/del (rs111200466)	Codomi-nant	ins/ins	316 (82.9)	112 (55.5)	1.00	< 0.0001	212 (78.8)	1.00	0.4100	1.00	< 0.0001
		ins/del	60 (15.8)	79 (39.1)	3.70 (2.41-5.70)		53 (19.7)	1.32 (0.88-1.98)		2.68 (1.71-4.20)
		del/del	5 (1.3)	11 (5.5)	5.73 (1.80-18.21)		4 (1.5)	1.19 (0.32-4.49)		5.06 (1.45-17.70)
	Dominant	ins/ins	316 (82.9)	112 (55.5)	1.00	< 0.0001	212 (78.8)	1.00	0.1900	1.00	< 0.0001
		ins/del	65 (17.1)	90 (44.5)	3.87 (2.55-5.86)		57 (21.2)	1.31 (0.88-1.94)		2.84 (1.84-4.39)
		del/del
	Recessive	ins/ins	376 (98.7)	191 (94.5)	1.00	0.0130	265 (98.5)	1.00	0.8500	1.00	0.0260
		ins/del
		del/del	5 (1.3)	11 (5.5)	4.00 (1.27-12.62)		4 (1.5)	1.13 (0.30-4.26)		3.77 (1.08-13.12)
	Overdo-minant	ins/ins	321 (84.2)	123 (60.9)	1.00	< 0.0001	216 (80.3)	1.00	0.1900	1.00	< 0.0001
		del/del
		ins/del	60 (15.8)	79 (39.1)	3.44 (2.24-5.27)		53 (19.7)	1.31 (0.87-1.97)		2.49 (1.59-3.88)
	Log-additive	---	---	---	3.23 (2.23-4.69)	< 0.0001	---	1.25 (0.88-1.79)	0.2200	2.54 (1.72-3.74)	< 0.0001
TLR2 19216T/C (rs3804099)	Codomi-nant	T/T	157 (41.2)	101 (50.0)	1.00	0.0920	131 (48.7)	1.00	0.1600	1.00	0.8900
		T/C	175 (45.9)	83 (41.1)	0.72 (0.49-1.06)		106 (39.4)	0.73 (0.52-1.01)		0.95 (0.63-1.44)
		C/C	49 (12.9)	18 (8.9)	0.56 (0.30-1.05)		32 (11.9)	0.78 (0.47-1.29)		0.85 (0.43-1.69)
	Dominant	T/T	157 (41.2)	101 (50.0)	1.00	0.0420	131 (48.7)	1.00	0.0580	1.00	0.7100
		T/T	224 (58.8)	101 (50.0)	0.68 (0.45-0.99)		138 (51.3)	0.74 (0.54-1.01)		0.93 (0.63-1.38)
		T/C
	Recessive	T/T	332 (87.1)	184 (91.1)	1.00	0.1600	237 (88.1)	1.00	0.7100	1.00	0.6800
		T/C
		C/C	49 (12.9)	18 (8.9)	0.65 (0.36-1.19)		32 (11.9)	0.91 (0.57-1.47)		0.87 (0.45-1.68)
	Overdo-minant	T/T	206 (54.1)	119 (58.9)	1.00	0.2500	163 (60.6)	1.00	0.0970	1.00	0.9000
		C/C
		T/C	175 (45.9)	83 (41.1)	0.81 (0.56-1.17)		106 (39.4)	0.77 (0.56-1.05)		0.98 (0.65-1.46)
	Log-additive	---	---	---	0.74 (0.56-0.97)	0.0300	---	0.83 (0.66-1.05)	0.1200	0.93 (0.69-1.26)	0.6400

C: Control; CG: Chronic gastritis; GC: Gastric cancer.