Adjuvant chemotherapy in curatively resected rectal cancer: How valid are the data?

Figure 3 Meta-analysis of n = 16 studies after the exclusion of all studies which found a statistically significant survival advantage in the experimental group. Each study included in the meta-analysis is represented on the forest plot by a box [put either in the region of favors (T) or favors (C) of the graphic according to the hazard ratio] and a line which indicates the 95% confidence interval. The pooled hazard ratio of the meta-analysis is represented by a diamond. In this case the estimate of overall effect is in the region which favors the treatment [favors (T)]. HR: Hazard ratio; CI: Confidence interval; W(fixed): Weight assigned to the study by using a fixed effect model; W(random): Weight assigned to the study by using a random effect model; Favors (T): Result in favor of the treatment (intervention) group (i.e., adjuvant chemotherapy after curative surgery); Favors(C): Result in favor of the control group (no adjuvant chemotherapy after surgery).