Adjuvant chemotherapy in curatively resected rectal cancer: How valid are the data?

Figure 1 Four steps to the analysis of validity of a systematic review. We identified the endpoint of interest (overall survival) and selected the three most powerful studies addressing this endpoint based on the assigned weights from the authors of the systematic review as these studies contributed essentially to the positive result of the systematic review. We finally assessed the validity of these studies by using the CONSORT checklist.