Efficacy of mesenchymal stem cells in the treatment of gastrointestinal malignancies

Figure 3 The effects of mesenchymal stem cells on liver cancer in different stages[80]. A: The experimental protocol. Rats were administrated N-diethylnitrosamine (DEN) in drinking water for 14 wk. DEN + mesenchymal stem cells (MSCs) (Is) group was transplanted MSCs (1 × 10⁶) by intravenous injection at 4^th, 6^th, 8^th week, and DEN + MSC (Ps) group was transplanted MSCs (1 × 10⁶) as the same method at the 10^th, 12^th, 14^th week, respectively. B: The rat percent survival in different groups. C: The macro phase and H&E images of liver in DEN and DEN + MSCs (Is) groups at 14 wk after DEN treatment. D: Tumor incidence, tumor max volume, and ratio of liver/body weight in DEN and DEN+MSCs (Is) groups at 14^th week. E: The macro phase and H&E images of liver in DEN and DEN + MSCs (Ps) groups at 16 weeks after DEN treatment. F: Tumor incidence, tumor max volume, and ratio of liver/body weight in DEN and DEN + MSCs (Ps) groups at 16^th week. DEN: N-diethylnitrosamine; MSCs: Mesenchymal stem cells; Is: Initial stage; Ps: Progressive stage; H&E: Hematoxylin-eosin.