Prognostic significance of systemic immune-inflammation index in patients with intrahepatic cholangiocarcinoma undergoing hepatic resection

Table 4 Multivariate analysis in the derivation cohort

Variables	Overall survival			Recurrence-free survival
	HR	95%CI	P value	HR	95%CI	P value
Hepatolithiasis	1.348	0.870-2.088	0.182
CA-199 (≥ 22/< 22)	1.458	0.979-2.170	0.064
Tumor size (≥ 5/<5)				0.873	0.556-1.371	0.555
Tumor number (multiple/single)	1.666	1.140-2.434	0.008	1.679	1.200-2.348	0.002
Tumor differentiation (moderate-poor/well)	3.061	0.739-12.675	0.123	2.813	0.877-9.022	0.082
Microvascular invasion	0.938	0.556-1.582	0.809
Node positive	2.377	1.586-3.562	< 0.001	1.881	1.316-2.688	0.001
TNM stage (III/I-II)	0.682	0.456-1.022	0.064	0.756	0.527-1.085	0.129
SII (> 450/≤ 450)	1.774	1.245-2.528	0.002	1.385	1.005-1.909	0.046

M: Male; F: Female; CA-199: Carbohydrate antigen-199; TNM: Tumor-node-metastasis; SII: Systemic immune-inflammation index; HR: Hazard ratio; CI: Confidence interval.