Circulating cytokines and outcome in metastatic colorectal cancer patients treated with regorafenib

Figure 1 Plasma cytokines levels. Basal evaluation of 6 cytokines in non-responder patients (n = 12), Responder patients (n = 5) and in healthy volunteers (n = 6). Cytokine concentration is expressed in pg/mL. Data are shown as median with range. The difference in median values was computed using the non-parametric Mann Whitney U test. P < 0.05 was considered the statistical significance. ^aP < 0.05 NR vs R; ^cP < 0.05 NR vs Healthy. NR: Non-responder; R: Responder; TNF-α: Tumor necrosis alpha; TGF-β: Transforming growth factor alpha; VEGF: Vascular endothelial growth factor; CCL-2: Chemokine ligand 2; CCL-4: Chemokine ligand 4; CCL-5: Chemokine ligand 5.