Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer

Table 6 Multivariate prognostic analysis for local recurrence-free survival and relapse-free survival

Factors	n	LFS						RFS
		Univariate			Multivariate			Univariate			Multivariate
		OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value	OR	95%CI	P value
Sex
Female	22
Male	60	1.91	0.21-17.7	0.56				1.13	0.36-3.60	0.83
Location from anal verge (cm)
≥ 5.0	29
< 5.0	53	1.10	0.19-6.41	0.91				1.89	0.61-5.89	0.26
Tumor diameter (cm)
< 4.5	42
≥ 4.5	40	2.00	0.86-2.89	0.43				0.63	0.22-1.74	0.37
cT
3	72
4	10	4.25	0.67-27.0	0.10	1.97	0.23-17.1	0.54	3.80	0.97-14.9	0.06	2.05	0.39-10.7	0.39
cN
−	36
+	46	1.62	0.28-9.38	0.59				1.25	0.34-2.60	0.90
Mesorectal fascia invasion
−	53
+	29	4.08	0.70-23.8	0.10	2.88	0.39-21.5	0.30	7.31	2.39-22.4	< 0.01	5.82	1.68-20.2	< 0.01
Extramural vascular invasion
−	46
+	36	2.75	0.47-15.9	0.24				3.15	1.10-9.03	0.03	3.42	1.02-11.5	0.04
Lateral lymph node (> 7.0 mm)
−	74
+	8	5.83	0.88-38.7	0.09	4.71	0.65-34.2	0.12	2.01	0.44-9.29	0.36
Histology
Well/moderately differentiated	66
Poorly differentiated/mucinous/signet	16	0.81	0.09-7.49	0.86				1.55	0.46-7.58	5.15

CI: Confidence interval; LFS: Local recurrence-free survival; OR: Odds ratio, RFS: Relapse-free survival.