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©The Author(s) 2020.
World J Gastrointest Oncol. Mar 15, 2020; 12(3): 311-322
Published online Mar 15, 2020. doi: 10.4251/wjgo.v12.i3.311
Published online Mar 15, 2020. doi: 10.4251/wjgo.v12.i3.311
Table 3 Associations between toxicity, feasibility and treatment effect and UGT1A1 polymorphisms, n (%)
| Wild type (n = 25) | Mutant type (n = 23) | P value | |
| Toxicity | |||
| Hematological toxicity (Grade 3 or 4) | 0 | 11 (47.8) | < 0.01 |
| Nonhematological toxicity (Grade 3 or 4) | 8 (32.0) | 6 (26.1) | 0.65 |
| Feasibility (%) | |||
| S-1 dose intensity (mean ± SD) | 90.9 ± 0.2 | 89.0 ± 0.2 | 0.38 |
| CPT-11 dose intensity (mean ± SD) | 93.0 ± 0.3 | 88.2 ± 0.2 | 0.26 |
| Treatment effect | |||
| Good response | 18 (72.0) | 22 (95.7) | < 0.01 |
| Poor response | 7 (28.0) | 1 (4.3) | |
| Pathological complete response | 5 (20.0) | 6 (26.1) | 0.61 |
- Citation: Kimura K, Beppu N, Doi H, Kataoka K, Yamano T, Uchino M, Ikeda M, Ikeuchi H, Tomita N. Impact of preoperative chemoradiotherapy using concurrent S-1 and CPT-11 on long-term clinical outcomes in locally advanced rectal cancer. World J Gastrointest Oncol 2020; 12(3): 311-322
- URL: https://www.wjgnet.com/1948-5204/full/v12/i3/311.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v12.i3.311