Association between interleukin-21 gene rs907715 polymorphism and gastric precancerous lesions in a Chinese population

Table 5 Haplotype analysis of polymorphisms in patients and controls

SNPs	Haplo-type	Control (n = 290, %)	NAG (n = 116, %)	AG (n = 106, %)	IM (n = 366, %)	χ2-1	P1 value	OR1	χ2-2	P2 value	OR2	χ2-3	P3 value	OR3
rs907715| rs12508721	CC	0.496	0.543	0.575	0.571	0.713	0.397	1.20 (0.78-1.86)	1.936	0.164	1.37 (0.88-2.15)	3.612	0.057	1.35 (1.00-1.84)
	CT	0.066	0.060	0.057	0.071	0.037	0.847	1.09 (0.45-2.67)	0.104	0.747	1.17 (0.45-3.01)	0.077	0.781	0.92 (0.50-1.69)
	TC	0.163	0.138	0.047	0.087	0.368	0.544	1.21 (0.66-2.23)	8.984	0.003	3.91 (1.51-10.11)	8.509	0.004	2.02 (1.25-3.26)
	TT	0.275	0.259	0.321	0.271	0.125	0.724	1.09 (0.67-1.78)	0.763	0.382	0.81 (0.50-1.31)	0.024	0.878	1.03 (0.73-1.45)
rs2221903| rs907715	CC	0.128	0129	0.123	0.158	0.002	0.963	0.99 (0.52-1.87)	0.017	0.896	1.05 (0.53-2.06)	1.264	0.264	0.78 (0.50-1.21)
	CT	0.006	0.026	0.019	0.014	2.450	0.118	0.26 (0.04-1.59)	1.113	0.292	0.36 (0.05-2.60)	0.701	0.404	0.50 (0.10-2.60)
	TC	0.434	0.474	0.509	0.484	0.527	0.468	0.85 (0.55-1.31)	1.759	0.185	0.74 (0.47-1.16)	1.571	0.210	0.82 (0.60-1.12)
	TT	0.432	0.371	0.349	0.344	1.244	0.265	1.29 (0.83-2.00)	2.158	0.142	1.41 (0.89-2.24)	5.157	0.023	1.44 (1.05-1.98)

Haplotype of rs907715(C/T), rs2221903 (T/C) and rs12508721(C/T). OR₁: NAG cases compared with controls; OR₂: AG cases compared with controls; OR₃: IM cases compared with controls. SNPs: Single nucleotide polymorphisms; NAG: Non-atrophic gastritis; AG: Atrophic gastritis; IM: Intestinal metaplasia.