Increased KIF21B expression is a potential prognostic biomarker in hepatocellular carcinoma

Table 3 Univariate and multivariate analyses of disease-free survival in 186 patients with hepatocellular carcinoma

Variable			Disease-free survival
		Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Age (> 55 yr vs ≤ 55 yr)	0.413	0.188-0.909	0.028a	0.464	0.284-0.759	0.002b
Gender (Male vs Female)	0.636	0.281-1.439	0.277
Tumor size (> 5 cm vs ≤ 5 cm)	1.928	0.775-4.975	0.158
Liver cirrhosis (Yes vs No)	1.285	0.724-2.280	0.392
TNM stage (I-IIvs III-IV)	0.709	0.423-1.188	0.192
HBsAg (Yes vs No)	0.790	0.480-1.313	0.356
AFP (> 400 ng/mL vs ≤ 400 ng/mL)	1.116	0.657-1.896	0.684
Vascular invasion (Yes vs No)	0.905	0.410-1.997	0.805
KIF21B expression (low vs high)	0.320	0.168-0.611	0.001b	0.373	0.216-0.643	< 0.001b

P < 0.05 was considered significant,

^aP < 0.05,

^bP < 0.01. Statistical analyses were performed using Cox regression analysis.