Increased KIF21B expression is a potential prognostic biomarker in hepatocellular carcinoma

Table 2 Univariate and multivariate analyses of overall survival in 186 patients with hepatocellular carcinoma

Variable			Overall survival
		Univariate			Multivariate
	HR	95%CI	P value	HR	95%CI	P value
Age (> 55 yr vs ≤ 55 yr)	0.489	0.195-1.225	0.293
Gender (Male vs Female)	0.726	0.291-1.809	0.491
Tumor size (> 5 cm vs ≤ 5 cm)	1.536	0.549-4.297	0.414
Liver cirrhosis (Yes vs No)	2.145	1.083-4.251	0.029a	1.188	0.712-1.81	0.510
TNM stage (I-II vs III-IV)	0.718	0.387-1.333	0.294
HBsAg (Yes vs No)	0.844	0.476-1.495	0.560
AFP (> 400 ng/mL vs ≤ 400 ng/mL)	1.576	0.842-2.949	0.155
Vascular invasion (Yes vs No)	0.554	0.233-1.316	0.181
KIF21B expression (low vs high)	0.212	0.093-0.482	< 0.001b	0.264	0.130-0.539	< 0.001b

P < 0.05 was considered significant,

^aP < 0.05,

^bP < 0.01. Statistical analyses were performed using Cox regression analysis.