Hepatic Hemangioendothelioma: An update

Table 4 Summary of liver transplant studies for hepatic hemangioepithelioma

Study	Year	Country	Liver transplant patients	Study Design	Reason for liver transplant	Outcome
Emamaullee et al[75]	2010	Canada	5/6 (1 patient did chemotherapy and surgical resection)	Retrospective	EHL (5/5), Recurrence (1/5)	1 patient had recurrence twice after two transplants but 2nd transplant resulted in stable disease. 1 patient had recurrence in less than 6 mo post-transplant and passed away less than 1 year post-transplant. 4 patients have stable disease post-transplant
Nudo et al[89]	2008	Canada	11/11	Retrospective	EHL	3/11 patients died (2 had recurrence while 1 died due to hepatic artery thrombosis). 4/11 patients had recurrence. 2/5 did surgical resection (both failed and 1/2 patients died at 61 mo post-resection while other patient did a second transplant and patient is still alive). 1/11 patients did radiotherapy. 1/11 patients assigned pegylated interferon and died 11 mo later
Rodriguez et al[69]	2007	United States	110/110	Retrospective	EHL	1/110 had operative death and 2/110 patients died within 30 d post-transplant. 1-year, 3-year, and 5-year overall survivals were 80%, 68%, and 64%, respectively. 31/110 were 5-year survivors. 38/110 patients died during follow-up. 12/38 patients died of recurrent EHL with distant involvement. 12/110 required re-transplantation including four patients who did a third transplant. For re-transplantation patients: 1-year, 3-year, and 5-year allograft survivals were 70%, 60%, and 55%, respectively
Mosoia et al[90]	2008	France	6/9	Retrospective	EHL	2/6 had recurrence and died (1 patient had recurrence and died at 56 mo while other patient had liver recurrence and died at 6 mo)
Lerut et al[58]	2007	France	59/59	Retrospective	EHL	Early (< 3 mo) and late (> 3 mo) post-LT mortality was 1.7% (1 patient) and 22% (14 patients). 14 (23.7%) patients with recurrence after a median time of 49 mo (range, 6-98). 9 (15.3%) patients died of recurrence and 5 survived with recurrent disease. Disease-free survival rates at 1, 5, and 10 yr post-liver transplant are 90%, 82%, and 64%
Mehrabi et al[2]	2006	Germany	128/286	Review	EHL	The most common management has been liver transplantation (44.8% of patients), followed by no treatment (24.8%), chemotherapy or radiotherapy (21%), and liver resection (9.4%). The 1-year and 5-year patient survival rates were 96% and 54.5%, respectively, after liver transplant; 39.3% and 4.5%, respectively, after no treatment, 73.3% and 30%, respectively, after chemotherapy or radiotherapy; and 100% and 75%, respectively, after liver resection
Jung et al[70]	2016	Korea	2/8	Retrospective	EHL	One patient died from tumor recurrence at 9 mo and the other is alive after 5 years without recurrence
Cardinal et al[91]	2009	United States	17/25	Retrospective	EHL	Mean survival of 172 (124-220) mo in the liver transplant group
Abdoh et al[71]	2017	Finland	1	Retrospective	EHL	Recurrence after 1 month and died 1 month later
Grotz et al[57]	2010	United States	11/30	Retrospective	EHL	1-, 3- and 5-year overall survival of 91%, 73% and 73% and a disease free survival of 64%, 46% and 46% respectively

EHL: Hepatic hemangioepithelioma.