Prognostic impact of at least 12 lymph nodes after neoadjuvant therapy in rectal cancer: A meta-analysis

Table 1 Characteristics of studies included in the meta-analysis

Ref.	Country	n	Age (yr)	Stage	Treatment	Surgery	Year of follow-up	Outcome
Wang et al[17], 2019	China	495	< 50: 160; > 50: 335	I-IV	Neoadjuvant treatment (RT 45-55 Gy + capecitabine)	AR, APR, Hartmann	No report	OS, DFS, LR, DR
Lykke et al[18], 2015	Denmark	2123	60-75	I-IV	Neoadjuvant treatment	TME	No report	OS
de Campos-Lobato et al[23], 2013	United States	237	57 (49-66)	II-III	Neoadjuvant treatment	LAR, APR	55 (36-77) mo	OS, DR, LR
Kim et al[20], 2015	South Korea	302	39-73	I-IV	Neoadjuvant treatment (IV 5-FU leucovorin or oral 5-FU based)	LAR, APR, CAA	57 mo	OS, DFS
Doll et al[22], 2009	Germany	102	18-75	I-IV	Neoadjuvant diochemotherapy (RT 45 Gy + 5-FU)	(L)AR, Miles	No reports	OS
La Torre et al[19], 2013	Italy	123	67.9 (27-91)	I-IV	Neoadjuvant diochemotherapy (RT 45 Gy + 5-FU)	LAR, APR	50 (9–120) mo	OS, DFS
Kim et al[24], 2015	South Korea	433	62 ± 11.1	I-IV	Perioperative chemoradiation (45.0–50.4 Gy + 5-FU and leucovorin)	TME	41.2 mo	DFS
Han et al[21], 2016	South Korea	458	60 (22-99)	I-III	Neoadjuvant treatment (RT 45–50.4 Gy + 5-FU)	TME	52 mo	OS, DFS
Klos et al[25], 2010	United States	221	53 ± 13	-	neoadjuvant treatment (RT 45.0–50.4 Gy + 5-FU)	TME	36 (21.6-63.6) mo	LR, DR

OS: Overall survival; DFS: Disease-free survival; DR: Distant recurrence; LR: Local recurrence; RT: Radiotherapy; 5-FU: 5-Fluorouracil; TME: Total mesolectal excision; APR: Abdominoperineal resection; LAR: Low anterior resection; CAA: Coloanal anastomosis; AR: Anterior resection.