Outcomes of neoadjuvant chemoradiotherapy followed by radical resection for T4 colorectal cancer

Table 5 Univariate and multivariate analyses for clinical parameters used to predict disease-free survival and overall survival

Variable	Disease-free survival			Overall survival
	Univariate P value	Multivariate		Univariate P value	Multivariate
		HR (95%CI)	P value		HR (95%CI)	P value
Age (< 60 vs ≥ 60 yrs)	0.492	0.770 (0.255-1.618)	0.492	0.729	0.621 (0.314-1.245)	0.177
Sex (female vs male)	0.493	0.773 (0.375-1.626)	0.493	0.678	0.906 (0.442-1.812)	0.783
Location (colon vs rectum)	0.353	0.216 (0.102-1.231)	0.153	0.346	0.291 (0.054-1.154)	0.082
cT stage (T4a vs T4b)	0.127	2.423 (0.604-9.836)	0.258	0.206	2.611 (0.752-9.054)	0.128
cN stage (N0 vs N+)	0.127	0.690 (0.139-3.014)	0.157	0.102	0.336 (0.094-1.087)	0.078
Tumor grade (WD/MD vs PD)	0.335	0.503 (0.098-1.936)	0.413	0.423	0.840 (0.247-2.500)	0.765
CEA (≤ 5 ng/mL vs > 5 ng/mL)	0.418	1.422 (0.614-3.391)	0.383	0.528	1.219 (0.581-2.622)	0.602
Neoadjuvant chemotherapy (FOLFOX vs Capecitabine)	0.142	3.549 (0.944-7.467)	0.082	0.117	2.846 (0.860-8.715)	0.158
Radiation dose (< 50 Gy vs ≥ 50 Gy)	0.351	0.291 (0.054-1.154)	0.182	0.327	2.525 (0.347-5.843)	0.221
Radiation-surgery interval (≤ 9 wk vs > 9 wk)	0.086	1.236 (0.792-5.276)	0.097	0.106	2.064 (0.589-7.062)	0.167
ypT stage (ypT3-4 vs ypT0-2)	0.237	2.484 (0.744-5.691)	0.636	0.097	2.150 (0.820-6.123)	0.121
ypN stage (ypN+ vs ypN0)	0.005	3.120 (1.245-8.357)	0.017a	0.073	1.771 (0.435-6.255)	0.405
Lymphovascular invasion (positive vs negative)	0.363	2.503 (0.724-7.788)	0.141	0.175	3.046 (0.961-9.081)	0.069
Perineural invasion (positive vs negative)	0.072	2.649 (0.869-8.976)	0.087	0.091	1.222 (0.323-4.078)	0.757
Resection margin (positive vs negative)	0.001	3.549 (1.004-12.747)	0.014a	0.013	4.136 (1.675-10.829)	0.001a
Pathological response (non-pCR vs pCR)	0.045	2.560 (1.186-6.013)	0.042a	0.031	2.977 (1.420-6.369)	0.003a

^aP < 0.05.

CEA: Carcinoembryonic antigen; MD: Moderately differentiated; pCR: Pathological complete response; PD: Poorly differentiated; WD: Well differentiated.