Comparison of survival between adolescent and young adult vs older patients with hepatocellular carcinoma

Table 1 Baseline characteristics of adolescent and young adult and older hepatocellular carcinoma patients

Characteristic		Total	AYA	Older	P value
		n = 12721	n = 366 (2.9%)	n = 12355 (97.1%)
Sex					< 0.001
	Male	10075	249 (68.0%)	9826 (79.5%)
	Female	2646	117 (32.0%)	2529 (20.5%)
Race					< 0.001
	White	8323	190 (51.9%)	8133 (65.8%)
	Black	1990	59 (16.1%)	1931 (15.6%)
	Other	2408	117 (32.0%)	2291 (18.5%)
Marital status					< 0.001
	Not married	2818	197 (53.8%)	2621 (21.2%)
	Married	9903	169 (46.2%)	9734 (78.0%)
SEER stage					< 0.001
	Localized	7264	178 (48.6%)	7086 (57.4%)
	Regional	3476	107 (29.2%)	3396 (27.3%)
	Distant	1981	81 (22.1%)	1900 (15.4%)
AJCC stage					< 0.001
	I	5063	118 (32.2%)	4945 (40.0%)
	II	2744	68 (18.6%)	2676 (21.7%)
	III	3036	105 (28.7%)	2931 (23.7%)
	IV	1878	75 (20.5%)	1803 (14.6%)
Grade					0.158
	I	3913	114 (31.3%)	3799 (30.7%)
	II	5719	141 (38.5%)	5578 (45.1%)
	III	2848	102 (27.9%)	2746 (22.2%)
	IV	241	9 (2.5%)	232 (1.9%)
Surgery					< 0.001
	No	6622	130 (35.5%)	6492 (52.5%)
	Yes	6099	236 (64.5%)	5863 (47.5%)
Radiation					0.319
	No	11862	346 (94.5%)	11516 (93.2%)
	Yes	859	20 (5.5%)	839 (6.8%)
Chemotherapy					0.306
	No	8074	223 (60.9%)	7851 (63.5%)
	Yes	4647	143 (39.1%)	4504 (36.5%)

AYA: Adolescent and young adult; HCC: Hepatocellular carcinoma; SEER: Surveillance, Epidemiology, and End Results; AJCC: American Joint Committee on Cancer; Grade I: Well differentiated; Grade II: Moderately differentiated; Grade III: Poorly differentiated; Grade IV: Undifferentiated.